Pair Name	Dihydroartemisinin, Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Ferroptosis
Gene Regulation	Down-regulation	Expression	GCLC	hsa2729
	Down-regulation	Expression	GPX4	hsa2879
	Down-regulation	Expression	GSS	hsa2937
	Down-regulation	Expression	HMOX1	hsa3162
	Up-regulation	Expression	ROS1	hsa6098
	Down-regulation	Expression	SLC7A11	hsa23657
	Up-regulation	Expression	SMG1	hsa23049
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
	SW480	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0546
In Vivo Model	5×10⁶ of HepG2 cells were injected into the right flank of 6-week-old athymic female mice (Balb/c nude mice).
Result	DHA and Sora had the same mechanism, and the combined application of them could have a synergistic anti-tumor effect by inducing ferroptosis and inhibiting energy metabolism in HepG2 cells.